EP2167 is the lead compound from a family of compounds whose apoptosis-inducing anti-tumor activities are mediated through the transferrin receptor via a rapid and novel molecular mechanism. Transferrin receptor is a known and validated oncology target, but in 2005 EpiCept published (Proc. Nat. Acad. Sci. USA, 102:12095-12100, 2005) the first evidence describing its role as a rapid inducer of apoptosis, a unique and different mechanism of its use as an oncology target. The transferrin receptor is located on the surface of cells and is over expressed in several types of cancer. In preclinical testing, EP2167 has been shown to induce apoptosis in multiple cancer cell types, including prostate, breast, colorectal, non-small cell and small cell lung cancers and leukemia, and has been shown to inhibit tumor growth in xenograft tumor cancer models of differert types.